Scientists May Have Discovered the Cause of Autism

While a correlation doesn't necessarily describe causation, at least this is a clue where to look.  The pop-science reporting encouraged me to test the capabilities of Meta AI to provide more detailed information.  (I have missed having access to a technical library.  Yes, I'm a happy camper.  More AI, please.)

The specific compound diHETrE is a shortened acronym for ' DiHydroxyoctadeca-9,11,13-trienoic acid Ethyl Ester'.  The compound diHETrE is a metabolic byproduct of linolenic acid, a polyunsaturated fatty acid (PUFA) found in various plant-based foods and oils.  PUFAs have been found to be beneficial in lowering LDL (bad cholesterol) and are recommended to be included in a balanced diet.  Some of these recommended foods include canola oil, walnut oil, flax seeds, hemp seeds, spinach, kale, and grass-fed (organic) beef and milk.

It's far to early to draw conclusions from the reported results but they should serve as a common sense reminder that too much of a good thing can be as harmful as too little.  The most important dietary recommendation is not adding magic foods and supplements but, instead, maintaining a balanced diet.  Dietary guidance used to be taught in public schools as part of Home Economics which has gone out of style for mostly political reasons.  

The United States Dept. of Agriculture (USDA) continues to be a valuable resource for dietary information and guidelines.  Dietary Guidelines for Americans  (Yes, the title should cause a giggle.)

S E E D E D   C O N T E N T

Scientists may have uncovered a link between the risk of autism in children and fatty acids in umbilical cord blood, but one Harvard professor told Newsweek more work needs to be done in the area.

To shed light on the possible causes of autism, researchers from the University of Fukui investigated the link between polyunsaturated fatty acids (PUFA) in umbilical cord blood samples and autism scores in 200 children.

They believe that this newfound knowledge could be "crucial" for understanding, diagnosing, and even preventing autism spectrum disorder (ASD).

The study identified one particular compound in the umbilical cord blood acid, called diHETrE, that may have "strong implications" for ASD severity.

"The levels of diHETrE, an arachidonic acid-derived diol, in cord blood at birth significantly impacted subsequent ASD symptoms in children and were also associated with impaired adaptive functioning," Hideo Matsuzaki, study author and child mental development professor at the University of Fukui, said in a statement.

"These findings suggest that the dynamics of diHETrE during the fetal period is important in the developmental trajectory of children after birth."

Specifically, the authors found that higher levels of diHETrE were associated with difficulties in social interactions, while low levels were linked to repetitive and restrictive behaviors in children. Notably, this correlation was more pronounced in girls than in boys.

The umbilical cord samples were collected and preserved immediately after the children's birth. ASD symptoms in these same children were then assessed at 6 years old with the help of their mothers.

Building on these results, the researchers suggest that measuring diHETrE levels at birth could soon become a valuable tool for predicting a child's risk of developing ASD.

"The effectiveness of early intervention for children with ASD is well established and detecting it at birth could enhance intervention and support for children with ASD," Matsuzaki added.

He also said that inhibiting diHETrE metabolism during pregnancy might be a promising avenue for preventing ASD traits in children, although more research will be needed in this area.

The study, published in Psychiatry and Clinical Neurosciences, builds on earlier research in mouse models that suggested PUFA and their metabolites during pregnancy play a crucial role in ASD development.

Sharing the motivation behind the research, Matsuzaki said: "CYP metabolism forms both epoxy fatty acids (EpFAs), which have anti-inflammatory effects, and dihydroxy fatty acids, or 'diols,' which have inflammatory properties."

"We hypothesized that the dynamics of CYP-PUFA metabolites during the fetal period, that is, lower EpFA levels, higher diol levels, and/or increased EpFA metabolic enzymes would influence ASD symptoms and difficulties with daily functioning in children after birth."

The study authors believe these findings "open a promising avenue" for unraveling the mysteries of ASD, potentially leading to improved diagnostics and treatment.

While he recognizes the area of research under focus in this study is emergent, James McPartland, professor of child psychiatry and psychology at Yale University School of Medicine, told Newsweek that the research does not provide information currently useful for diagnosing ASD.

"This is an exploratory study investigating potential mechanisms for autism clinical features that are not established and presently not well understood. Its significance lies in generating hypotheses to be tested in more rigorous future studies, but it provides limited information on which to draw conclusions or guide clinical decision-making," he said.

McPartland also noted that prevention of ASD is not an objective of most autism clinicians and researchers. Instead, the primary objective is to advance research and develop insights that can enhance the quality of life for autistic individuals and their families.

"Of note, the autism diagnostic observation schedule used in this study is not a sufficiently sensitive and specific diagnostic tool when used in isolation. It is most reliable when combined with parent interviews and clinical judgment according to DSM-5 diagnostic criteria," he added.

From the published data, it cannot be determined what proportion of the individuals studied would actually meet diagnostic criteria for autism. In this way, the study provides very limited information about potential diagnostic utility of these methods, he said.

Update 07/31/24, 13:48 a.m. ET: This article was updated with additional comments from James McPartland.