Marijuana Study Finds CBD Can Cause Liver Damage

  
Via:  dean-moriarty  •  4 months ago  •  23 comments

Marijuana Study Finds CBD Can Cause Liver Damage
Regardless of your feelings on this particular study, it is hard to argue with dead mice – even if you are an all-knowing marijuana expert.

S E E D E D   C O N T E N T


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There is no denying that cannabidiol, more commonly referred to as CBD, is rapidly becoming more popular in the United States than sliced bread. It is a hot trend that got started several years ago after  Dr. Sanja Gupta showed the nation in his documentary 'Weed 2' just how this non-intoxicating component of the cannabis plant was preventing epileptic children from having seizures. 

Since then, CBD, a substance often touted as being safer than popping pills, has risen to infamy as an alternative treatment for a variety of common ailments from anxiety to chronic pain. But a new study suggests that CBD may spawn its fair share of health issues. Specifically, scientists have learned that this substance could be damaging our livers in the same way as alcohol and other drugs. 

Researchers at the University of Arkansas for Medical Science recently rolled up their sleeves to investigate CBD hepatotoxicity in mice. What they found was while this cannabis derivative is gaining significant recognition as of late in the  world of wellness , people that use CBD are at an elevated risk for liver toxicity.

The findings, which were published earlier this year in the  journal Molecules , suggest that while people may be using CBD as a safer alternative to conventional pain relievers, like acetaminophen, the compound may actually be just as harmful to their livers. 

It is the methods used in this study that makes it most interesting.

First, researchers utilized all of the dosage and safety recommendations from a CBD-based drug known as Epidiolex. If this name sounds familiar, it should. Last year, the U.S. Food and Drug Administration  approved it as a treatment for certain kinds of childhood epilepsy. It was a development that marked the first time in history that a cannabis-based medicine was approved for nationwide distribution in the United States. 

Researchers then spent some time examining mice under the influence of various doses of CBD. Some of the animals received lower doses, while others were given more. The dosage is said to have been "the allometrically scaled mouse equivalent doses (MED) of the maximum recommended human maintenance dose of CBD in EPIDIOLEX (20 mg/kg)." 

Shockingly, researchers discovered that the mice given higher doses of CBD showed signs of liver damage within 24 hours. To that end, 75 percent of these animals in the sub-acute phase had either died or were on the verge of death within a few days. 

Regardless of your feelings on this particular study, it is hard to argue with dead mice – even if you are an all-knowing  marijuana expert

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Liver toxicity is an adverse reaction to various substances. Alcohol, drugs and even some natural supplements can all take their toll on liver function – even in healthy individuals. But this is the first study of its kind indicating that CBD might be just as detrimental to the human liver as other chemicals. 

But come to find out, there has been evidence of CBD's havoc wreaking ways on the liver for some time. 

Lead study author Igor Koturbash, PhD, recently told the health site  Nutra Ingredients USA that the risk of liver damage from CBD is a nasty side effect printed in black and white on GW Pharma's Epidiolex packaging. 

"If you look at the Epidolex label,"  he said , "it clearly states a warning for liver injury. It states you have to monitor the liver enzyme levels of the patients. In clinical trials, 5% to 20% of the patients developed elevated liver enzymes and some patients were withdrawn from the trials," he added. 

In other words, anyone taking CBD regularly and in higher doses might unwittingly find themselves on the road to liver disease. 

Previous studies have also suggested that certain components of the cannabis plant may be harmful to the liver. Although one study found that marijuana  may actually help prevent liver damage in people with alcoholism , in some cases it worsened the condition.

“Patients with hepatitis C who used cannabis had way more liver scarring than those who didn’t and more progression of their liver disease. Something in the cannabis could actually be increasing fatty liver disease,” Dr. Hardeep Singh, gastroenterologist at St. Joseph Hospital in Orange, California, told Healthline

But wait, it gets worse.

The latest study also finds that CBD has the potential for herbal and drug interactions. "CBD differentially regulated more than 50 genes, many of which were linked to oxidative stress responses, lipid metabolism pathways and drug metabolizing enzymes,"  the study reads .

However, Dr. Koturbash was quick to point out that the CBD products coming to market may not pose this particular risk. What he is sure of, however, is that more research is needed on CBD to evaluate its overall safety.

As it stands, none of the CBD products being sold in grocery stores and malls all over the nation have received FDA approval. And the only CBD-based medicine that has been approved, Epidiolex, is apparently stamped with a big, fat warning of potential liver damage. 

Sounds like we might as well be medicating with vodka, folks! Just tell the bartender to hold the bonus shot of CBD. 

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Sparty On
1  Sparty On    4 months ago

Well .... this is not good.

 
 
 
Dismayed Patriot
1.1  Dismayed Patriot  replied to  Sparty On @1    4 months ago
Well .... this is not good.

It's always wise to be cautious. I do feel this is a bit misleading as the headline doesn't exactly tell the truth.

"Marijuana Study Finds CBD Can Cause Liver Damage"

But what does the article say?

"First, researchers utilized all of the dosage and safety recommendations from a CBD-based drug known as Epidiolex."

Epidiolex is not just CBD oil, it is a manufactured patented mix of compounds that include CBD made by GW Reseacrh LTD.

Drug companies know they can't make money off just testing CBD oil, they can't patent it on its own, they have to mix it with shit so they can be granted a uniqie patent so they can make a profit off a new "sterilized" pill form of marijuana sold as seizure medicine.

I'm not saying the CBD didn't have anything to do with the elevated liver toxicity, but I think we need far more real open studies than just listening to one misleading study that only tested a drug company compound.

And obviously the results of the testing done are mixed as it points out "one study found that marijuana may actually help prevent liver damage in people with alcoholism, in some cases it worsened the condition".

More testing needs to be done, there is no reason at this stage to throw the baby out with the bathwater so to speak. Besides, most of the current drugs they sell on TV now have side effects that include everything from anal leakage, vomiting to even death. So when compared to many other drugs used for certain afflictions like epilepsy, it appears to have great results with few side effects when taken at the proper low doses of which the study says they did not see such a spike in liver toxicity as they did with the very high dose mice.

 
 
 
Sparty On
1.1.1  Sparty On  replied to  Dismayed Patriot @1.1    4 months ago
More testing needs to be done

That's exactly what the article sez ..... in the meantime one would be prudent to be advised and concerned.

That said i've heard that small quantities of saliva, swallowed over long periods of time, can cause cancer.  

So there you go.

 
 
 
epistte
1.1.2  epistte  replied to  Dismayed Patriot @1.1    4 months ago
And obviously the results of the testing done are mixed as it points out "one study found that marijuana may actually help prevent liver damage in people with alcoholism, in some cases it worsened the condition". More testing needs to be done, there is no reason at this stage to throw the baby out with the bathwater so to speak. Besides, most of the current drugs they sell on TV now have side effects that include everything from anal leakage, vomiting to even death. So when compared to many other drugs used for certain afflictions like epilepsy, it appears to have great results with few side effects when taken at the proper low doses of which the study says they did not see such a spike in liver toxicity as they did with the very high dose mice.

CBD is not commonly made from marijuana. It's made from hemp, which has no THC. 

 
 
 
†hε pε⊕pレε'š ƒïšh
1.1.3  †hε pε⊕pレε'š ƒïšh  replied to  epistte @1.1.2    4 months ago

“Hemp” is a term used to classify varieties of cannabis that contain 0.3% or less THC content 

"Marijuana” is a term used to classify varieties of Cannabis that contain more than 0.3% THC content

 
 
 
epistte
1.1.4  epistte  replied to  †hε pε⊕pレε'š ƒïšh @1.1.3    4 months ago
“Hemp” is a term used to classify varieties of cannabis that contain 0.3% or less THC content  "Marijuana” is a term used to classify varieties of Cannabis that contain more than 0.3% THC content

I am well aware of that.

 
 
 
†hε pε⊕pレε'š ƒïšh
1.1.5  †hε pε⊕pレε'š ƒïšh  replied to  epistte @1.1.4    4 months ago

It didn't appear that way from your statement but now you know for sure.

It's made from hemp, which has no THC. 

Not exactly true....

 
 
 
epistte
1.1.6  epistte  replied to  †hε pε⊕pレε'š ƒïšh @1.1.5    4 months ago
Not exactly true....

0.3% is the legal amount for sale without a 'script. 

 
 
 
†hε pε⊕pレε'š ƒïšh
1.1.7  †hε pε⊕pレε'š ƒïšh  replied to  epistte @1.1.6    4 months ago

Yes, we are all aware of that however if the plant contains .03% THC, it does not mean the plant has no THC.

 
 
 
epistte
1.1.8  epistte  replied to  †hε pε⊕pレε'š ƒïšh @1.1.7    4 months ago
Yes, we are all aware of that however if the plant contains .03% THC, it does not mean the plant has no THC.

It is minimal and quicky metabolized, unless you are ingesting a large amount of CBD.  Most drug tests show a false positive that is quickly ruled out for marijuana.

Where is this conversation going? 

Because THC is widely recognized as being responsible for marijuana’s psychoactivity and euphoria , a routine urine drug screen for marijuana use consists of an immunoassay with antibodies that are made to detect it, and its main metabolite, 11-nor-delta9-caboxy-THC (THC-COOH). SAMHSA has set the cutoff level for a positive urine screen in the immunoassay at 50 ng/mL. When the immunoassay screen is positive at the > 50 ng/mL level, a confirmatory GC/MS (Gas Chromatography/Mass Spectrometry) test is performed to verify the positive urine screen. The confirmatory GC/MS has a cutoff level of 15 ng/mL and is specific only to the 11-nor-THCCOOH metabolite.

Fortunately, the urine drug screen for THC-COOH is known to have very little cross-reactivity to other cannabinoids that are not intoxicating, such as CBD (cannabidiol), CBG (cannabigerol), CBN (cannabinol), and others. This is good news for “normal” consumers of CBD/hemp oil .

That said, individuals using unusually large doses of a cannabinoid-rich hemp oil product (above 1000-2000 mg of hemp oil daily) could theoretically test positive during the initial urinary screen. Although very rare, the urine screen in these cases would likely represent a “false positive” due to other non-THC metabolites or compounds, which may cross-react with the immunoassay. When this is the case, the confirmatory GC/MS test would be negative, since CBD and other cannabinoids will not be detected by the more accurate (and specific) GC/MS screen.

https://www.leafly.com/news/cannabis-101/does-using-cbd-hemp-oil-result-in-a-positive-drug-test-for-thc-or

 
 
 
Dean Moriarty
1.1.9  seeder  Dean Moriarty  replied to  epistte @1.1.6    4 months ago

We can get it with a ten parts THC to one part CBD ratio here without a script. A one ounce bottle has 100 mg of THC and only 10 mg of CBD for recreational sales. You can get higher than 100mg of THC if you have a medical card here but they limit recreational edibles to 100mgs here. There is a wide range of ratios available for sale here. It varies from state to state. 

512

 
 
 
epistte
1.1.10  epistte  replied to  Dean Moriarty @1.1.9    4 months ago

You cannot buy that in Ohio. The government in Columbus is still claiming that CBD is not technically legal, despite the 2018 Farm Bill.

Do you live in a state with recreational marijuana?

 
 
 
Dean Moriarty
1.1.11  seeder  Dean Moriarty  replied to  epistte @1.1.10    4 months ago

Yes Colorado. 

 
 
 
epistte
1.1.12  epistte  replied to  Dean Moriarty @1.1.11    4 months ago
Yes Colorado. 

That is different from Ohio. The Republicans in Columbus are still playing around and trying to delay the process for implementing medical marijuana that we voted for.  They have corporate interests to protect.    There are only 10 Drs in the state that can issue you a permit to buy medical marijuana.

I wish we would just legalize it as recreational and get it over with as rational states have. 

 
 
 
Dean Moriarty
2  seeder  Dean Moriarty    4 months ago

I've been taking a ten parts CBD to 1 part THC tincture for about a year now. I'm considering discontinuing the treatment as I do more research and learn more on the potential harmful side effects of CBD.

 
 
 
†hε pε⊕pレε'š ƒïšh
2.1  †hε pε⊕pレε'š ƒïšh  replied to  Dean Moriarty @2    4 months ago

Great article Dean, we all need to weight the potential side effects versus the benefits of using CBD oil. Research is clearly needed. I've been using CBD for awhile and my liver panel was in incredible shape. It's important though to get it tested yearly.

 
 
 
Sparty On
2.1.1  Sparty On  replied to  †hε pε⊕pレε'š ƒïšh @2.1    4 months ago

I haven't bit on the CBD oils yet.  

I still self medicate old school using CH3CH2OH .... sometimes the clear stuff, sometimes the dirty brown water stuff .......

 
 
 
Perrie Halpern R.A.
2.1.2  Perrie Halpern R.A.  replied to  Sparty On @2.1.1    4 months ago

I have been considering using it, since I am on 2 epileptic drugs for over 30 years now and I would like to come off of them. 

Even FDA approved drugs have their issues. 

Not sure how to proceed.

 
 
 
Sparty On
2.1.3  Sparty On  replied to  Perrie Halpern R.A. @2.1.2    4 months ago

This is great example of the FDA not doing their job.   This stuff has been around for quite awhile and has many potential benefits.   That it hasn't been approved/disapproved by the FDA yet is a travesty.

 
 
 
bbl-1
2.1.4  bbl-1  replied to  Perrie Halpern R.A. @2.1.2    4 months ago

Discuss this matter with your Doctor. 

*unless he is a birther*

 
 
 
Freefaller
2.2  Freefaller  replied to  Dean Moriarty @2    4 months ago

As DP said above more study is needed but most medications do come with bad side effects and it's a matter of judging risk vs reward when taking them.

 
 
 
MUVA
3  MUVA    4 months ago

My study shows if I smoke pot I get high.I was actually going to get some oil a few of my friends use CBD oil with good results.

 
 
 
bbl-1
4  bbl-1    4 months ago

CBD causes liver problems?  Possibly.

So does alcohol, fracking waste in the water supplies and certain industrial chemicals in the air we breathe.

 
 
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