Drug could regrow hair in some with hair loss
Drug could regrow hair in some with hair loss
Most hair-loss drugs currently available may stop hair loss, but don't cause hair to regrow. Now, new research suggests that a drug already used to treat people with other conditions could restore hair growth in patients with one disease that can cause hair loss.
In a small new study, three people who took a drug called ruxolitinib daily for four to five months saw a complete regrowth of their hair. The patients had a condition called alopecia areata, which is an autoimmune disease that causes the loss of hair from the scalp or other areas of the body.
The drug used in the study is already approved by the Food and Drug Administration to treat people with myelofibrosis, a serious bone marrow disorder.
In the new study, the investigators also determined the cellular mechanism that causes hair loss in people with alopecia areata, which was not completely understood before.
"Additional clinical trials are needed to test the effectiveness of this drug in more patients in larger studies," said study author Angela M. Christiano, a professor of dermatology and genetics at Columbia University Medical Center in New York. "However, for patients with alopecia areata, this is an exciting result, because it offers a potential new class of drugs that have not been tried before in this disease, with some promising early results." [ 4 Common Skin Woes, and How to Fix Them ]
There is currently no approved treatment that can restore hair in patients with alopecia areata, which usually starts with the loss of small patches of hair on the scalp. In some cases, the condition can lead to the loss of all hair on the scalp or body.
Alopecia areata affects about 2 percent of the population, and about 6.5 million people in the United States have it, according to the National Alopecia Areata Foundation. The course of the disease is highly unpredictable patients' hair may grow back and fall out again at any point and differs from one patient to another. People with alopecia often suffer psychologically and emotionally.
Researchers already knew that hair loss in people with alopecia occurs when cells of the immune system attack the base of the hair follicles . But until now, it was not clear which type of cell was responsible for this attack.
In the new study, the investigators found that a certain set of T cells are responsible for attacking hair follicles, and they also determined how those cells receive instructions to attack hair follicles. The investigators identified key immune pathways that could be targeted by drugs called JAK inhibitors.
Prior to the testing the drug on people with alopecia, the researchers tested two FDA-approved JAK inhibitors ruxolitinib and tofacitinib on mice with extensive hair loss from the disease, and found that the drugs effectively stopped the attack of T cells on hair follicles. Within 12 weeks of treatment, the drugs completely restored the mice's hair, and the hair remained for several months after stopping the treatment.
When the researchers tested ruxolitinib in the three people with the disease, they found that the attacking T cells disappeared from their scalps, and the patients regrew their hair.
"We believe this is a very exciting step forward for the treatment of alopecia areata," Christiano told Live Science. "We hope these findings will inspire future efforts to pursue the development of JAK inhibitors for this disease and represent a first rationally-selected treatment based on some exciting new scientific findings."
The researchers have not so far observed any adverse effects of ruxolitinib in their small trial, Christiano said.
"In patients who do not have chronic illnesses and are otherwise healthy, the likelihood of side effects [from taking ruxolitinib] is smaller thanin patients who have chronic illnesses," she said. "Side effects can include infection, and changes in certain blood tests such as a drop in platelets or anemia."
The new study was published online today (Aug. 17) in the journal Nature Medicine.
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This is great news for people with significant hair loss!!
I'm getting a haircut this week, and am willing, for a small fee, to donate 6 inches of hair to anyone that contacts me at, ''I've got hair''..
Sure is fantastic news, Nona! Going to print out the info and take it with me to the doc this week! Thanks a bunch!
KAV...why don't you get them ALL cut...
You're welcome!
So, we won't have to give our visitors sunglasses when they talk with us????
LOL I need to show this article to hubby!
I think only Raid would on anteaters!!
1st, OK, smart ass. Hmmmm...........I did notice last time we went out to breakfast that you were wearing sunglasses. You owe me a breakfast for that comment.
Nope, I have to leave it at least to my shoulder blades.
Gosh. This isn't a topical application, from what I'm gathering, but a pill you take? Wow!
I really hope this turns out to be as good as they're saying. Topicals don't work and the frickin' injections hurt like hell but you do what you have to do with what they offer...not many alternatives out there that work.
Alright smart guy...get them ALL cut, but leave them shoulder length!!
That's the truth!